Molecular Pathology Core Laboratory (MPCL)

Overview of Services

The Molecular Pathology Core Laboratory group works to advance molecular pathology-based, cancer research. The group addresses significant scientific and clinical research needs, and has created a central hub where researchers can interact, collaborate, and utilize novel molecular pathology technologies to translate basic science discoveries into patient care applications for cancer. Our mission comprises comprehensive pathology annotation to encompass clinical, morphological and molecular characteristics, genetic discovery in primary human tumors, with limited material and in real time, novel biomarker identification and pre-clinical trials and transitioning assays to the clinical setting.

 

 

Molecular Pathology Core Lab Website

 

 

Inquiries? Please contact us at DFCI_Pathology@dfci.harvard.edu 

 

 

Leadership

Jon Christopher Aster, M.D., Ph.D.
Chair
Department of Oncologic Pathology
Jaster@rics.bwh.harvard.edu
 

Sabina Signoretti, M.D.
Associate Director
Molecular Pathology Core Laboratory
SSignorett@BWH.Harvard.edu
  

Staff

Ying Huang, M.D., Ph.D.
Research Scientist

 

Madison L O'Donnell
Technician

 

Nicolas Hayden
Technician

 

Bryan Hickey
Administrator

 

Hours of Operation and Location

9:00am - 5:00pm                         450 Brookline Avenue, Jimmy Fund 2nd Floor, Boston, MA  02215

Monday - Friday                              

 

MPCL Service Pricing         
Service  Name Unit DFCI External Corporate
Histology Service        
Paraffin Tissue Processing & Embedding Block 12.89 17.41 25.14
Paraffin Tissue Sectioning, first slide Slide  6.92 9.34 13.50
Tissue sectioning, additional slide Slide  4.14 5.59 8.07
Paraffin Tissue Sectioning, TMA Slide  6.92 9.34 13.50
Frozen Tissue Embedding Block 15.16 20.46 29.55
Frozen Sectioning Slide  8.23 11.11 16.05
H&E Staining Slide  4.97 6.71 9.69
Bone Tissue Decalcification sample 31.44 42.44 61.31
Cell Pellet Making, Processing & Embedding each 111.12 150.01 216.68
Coring Block/ Scraping slide for DNA/RNA Extraction Slide  6.92 9.34 13.50
         
IHC Service (Primary Antibody not included)        
Antibody Optimization EA 300.00 405.00 585.00
IHC staining Slide 36.96 49.89 72.06
IHC Double Staining_chromogenic Slide 63.69 85.98 124.20
Multi-plex FIHC Optimization Panel 800.00 1080.00 1560.00
Multi-plex FIHC_Mono control Slide 65.00 87.75 126.75
Multi-plex FIHC_3 markers Slide  95.00 128.25 185.25
Multi-plex FIHC_4 markers Slide  125.00 168.75 243.75
Multi-plex FIHC_5 markers Slide  155.00 209.25 302.25
Multi-plex FIHC_ 6 markers Slide  185.00 249.75 360.75
         
InSitu hybridization (Probe/KIT not included)        
RNA ISH Optimization Probe 500.00 675.00 975.00
RNA ISH Slide  123.76 167.08 241.33
Multiplex Fluorecense RNA ISH Slide  123.76 167.08 241.33
         
TUNEL        
TUNEL Staining Slide 98.92 133.54 192.88
         
LCM        
Equipment Use (core operated) Hour 49.53 66.87 96.58
LCM Training_Base charge (including supplies, reagents and tissues) Round 500.00 675.00 975.00
Equpment Access for Trained Users (user prepare all
supplies)
Hour 48.15 64.99 93.87
         
Spectral Imaging         
Whole Slide Scan (10x) - Brightfield  Slide 9.00 12.00 16.00
Whole Slide Image Acquisition (20x) - Brightfield  Slide 18.00 24.00 31.00
TMA Whole Slide Scan  (10X)- Brightfield Slide 10.00 13.50 18.00
TMA Whole Slide Image Acquisition (20x) - Brightfield  Slide 30.00 40.00 53.00
Whole Slide Image Acquisition (10x) - Fluorescence Slide 16.00 20.00 28.00
Whole Slide Image Acquisition (20x) - Fluorescence_Biopsy Slide 50.00 68.00 88.00
Whole Slide Image Acquisition (20x) - Fluorescence_Non-Biopsy Slide 80.00 100.00 140.00
Image Analysis Software Usage - Brightfield  per 100 ROI 200.00 270.00 350.00
Image Analysis Software Usage - Fluorescence  per 100 ROI 400.00 500.00 700.00
         
Molecular Pathology         
DNA Extraction and Quant_for LCM or scraping samples sample 65.00 75.00 90.00
RNA Extraction and Quant_for LCM or scraping samples sample 65.00 75.00 90.00
DNA/RNA QC_Bioanalyzer sample 12.00 15.00 20.00
Labour Charge        
Histology Tech Hour 27.42 34.55 47.99
Immunohistology Tech Hour 33.43 45.13 65.19
LCM Tech Hour 33.43 45.13 65.19
Scientist  Hour 80.00 108.00 156.00

 

 




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