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The Molecular Pathology Core Laboratory group works to advance molecular pathology-based, cancer research. The group addresses significant scientific and clinical research needs, and has created a central hub where researchers can interact, collaborate, and utilize novel molecular pathology technologies to translate basic science discoveries into patient care applications for cancer. Our mission comprises comprehensive pathology annotation to encompass clinical, morphological and molecular characteristics, genetic discovery in primary human tumors, with limited material and in real time, novel biomarker identification and pre-clinical trials and transitioning assays to the clinical setting.
Molecular Pathology Core Lab Website
Inquiries? Please contact us at DFCI_Pathology@dfci.harvard.edu
Jon Christopher Aster, M.D., Ph.D.
Chair
Department of Oncologic Pathology
Jaster@rics.bwh.harvard.edu
Sabina Signoretti, M.D.
Associate Director
Molecular Pathology Core Laboratory
SSignorett@BWH.Harvard.edu
Ying Huang, M.D., Ph.D.
Research Scientist
Madison L O'Donnell
Technician
Nicolas Hayden
Technician
Bryan Hickey
Administrator
9:00am - 5:00pm 450 Brookline Avenue, Jimmy Fund 2nd Floor, Boston, MA 02215
Monday - Friday
| MPCL Service Pricing | ||||
| Service Name | Unit | DFCI | External | Corporate |
| Histology Service | ||||
| Paraffin Tissue Processing & Embedding | Block | 12.89 | 17.41 | 25.14 |
| Paraffin Tissue Sectioning, first slide | Slide | 6.92 | 9.34 | 13.50 |
| Tissue sectioning, additional slide | Slide | 4.14 | 5.59 | 8.07 |
| Paraffin Tissue Sectioning, TMA | Slide | 6.92 | 9.34 | 13.50 |
| Frozen Tissue Embedding | Block | 15.16 | 20.46 | 29.55 |
| Frozen Sectioning | Slide | 8.23 | 11.11 | 16.05 |
| H&E Staining | Slide | 4.97 | 6.71 | 9.69 |
| Bone Tissue Decalcification | sample | 31.44 | 42.44 | 61.31 |
| Cell Pellet Making, Processing & Embedding | each | 111.12 | 150.01 | 216.68 |
| Coring Block/ Scraping slide for DNA/RNA Extraction | Slide | 6.92 | 9.34 | 13.50 |
| IHC Service (Primary Antibody not included) | ||||
| Antibody Optimization | EA | 300.00 | 405.00 | 585.00 |
| IHC staining | Slide | 36.96 | 49.89 | 72.06 |
| IHC Double Staining_chromogenic | Slide | 63.69 | 85.98 | 124.20 |
| Multi-plex FIHC Optimization | Panel | 800.00 | 1080.00 | 1560.00 |
| Multi-plex FIHC_Mono control | Slide | 65.00 | 87.75 | 126.75 |
| Multi-plex FIHC_3 markers | Slide | 95.00 | 128.25 | 185.25 |
| Multi-plex FIHC_4 markers | Slide | 125.00 | 168.75 | 243.75 |
| Multi-plex FIHC_5 markers | Slide | 155.00 | 209.25 | 302.25 |
| Multi-plex FIHC_ 6 markers | Slide | 185.00 | 249.75 | 360.75 |
| InSitu hybridization (Probe/KIT not included) | ||||
| RNA ISH Optimization | Probe | 500.00 | 675.00 | 975.00 |
| RNA ISH | Slide | 123.76 | 167.08 | 241.33 |
| Multiplex Fluorecense RNA ISH | Slide | 123.76 | 167.08 | 241.33 |
| TUNEL | ||||
| TUNEL Staining | Slide | 98.92 | 133.54 | 192.88 |
| LCM | ||||
| Equipment Use (core operated) | Hour | 49.53 | 66.87 | 96.58 |
| LCM Training_Base charge (including supplies, reagents and tissues) | Round | 500.00 | 675.00 | 975.00 |
| Equpment Access for Trained Users (user prepare all supplies) |
Hour | 48.15 | 64.99 | 93.87 |
| Spectral Imaging | ||||
| Whole Slide Scan (10x) - Brightfield | Slide | 9.00 | 12.00 | 16.00 |
| Whole Slide Image Acquisition (20x) - Brightfield | Slide | 18.00 | 24.00 | 31.00 |
| TMA Whole Slide Scan (10X)- Brightfield | Slide | 10.00 | 13.50 | 18.00 |
| TMA Whole Slide Image Acquisition (20x) - Brightfield | Slide | 30.00 | 40.00 | 53.00 |
| Whole Slide Image Acquisition (10x) - Fluorescence | Slide | 16.00 | 20.00 | 28.00 |
| Whole Slide Image Acquisition (20x) - Fluorescence_Biopsy | Slide | 50.00 | 68.00 | 88.00 |
| Whole Slide Image Acquisition (20x) - Fluorescence_Non-Biopsy | Slide | 80.00 | 100.00 | 140.00 |
| Image Analysis Software Usage - Brightfield | per 100 ROI | 200.00 | 270.00 | 350.00 |
| Image Analysis Software Usage - Fluorescence | per 100 ROI | 400.00 | 500.00 | 700.00 |
| Molecular Pathology | ||||
| DNA Extraction and Quant_for LCM or scraping samples | sample | 65.00 | 75.00 | 90.00 |
| RNA Extraction and Quant_for LCM or scraping samples | sample | 65.00 | 75.00 | 90.00 |
| DNA/RNA QC_Bioanalyzer | sample | 12.00 | 15.00 | 20.00 |
| Labour Charge | ||||
| Histology Tech | Hour | 27.42 | 34.55 | 47.99 |
| Immunohistology Tech | Hour | 33.43 | 45.13 | 65.19 |
| LCM Tech | Hour | 33.43 | 45.13 | 65.19 |
| Scientist | Hour | 80.00 | 108.00 | 156.00 |
| ► Molecular Pathology (1) | |||
| Name | Description | Price | |
|---|---|---|---|
| DNA/RNA QC_Bioanalyzer |
Quality control for the DNA/RNA extracted from the LCM or scraping tissues |
Inquire | |
