Welcome!
The Molecular Pathology Core Laboratory group works to advance molecular pathology-based, cancer research. The group addresses significant scientific and clinical research needs, and has created a central hub where researchers can interact, collaborate, and utilize novel molecular pathology technologies to translate basic science discoveries into patient care applications for cancer. Our mission comprises comprehensive pathology annotation to encompass clinical, morphological and molecular characteristics, genetic discovery in primary human tumors, with limited material and in real time, novel biomarker identification and pre-clinical trials and transitioning assays to the clinical setting.
Molecular Pathology Core Lab Website
Inquiries? Please contact us at DFCI_Pathology@dfci.harvard.edu ;
Kathleen H. Burns, M.D., Ph.D.
Chair
Department of Oncologic Pathology
Pamela Groen
Associate Director
Kristen Au
Senior Research Technician
9:00am - 5:00pm 450 Brookline Avenue, Jimmy Fund 2nd Floor, Boston, MA 02215
Monday - Friday
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MPCL Service Pricing |
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Service Name |
Unit |
DFCI |
External |
Corporate |
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Histology Service |
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Paraffin Tissue Processing & Embedding |
Block |
12.89 |
17.41 |
25.14 |
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Paraffin Tissue Sectioning, first slide |
Slide |
6.49 |
8.76 |
12.66 |
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Tissue sectioning, additional slide |
Slide |
3.67 |
4.95 |
7.16 |
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Paraffin Tissue Sectioning, TMA |
Slide |
10.00 |
13.50 |
19.50 |
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Frozen Tissue Embedding |
Block |
20.00 |
27.00 |
39.00 |
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Frozen Sectioning |
Slide |
8.23 |
11.11 |
16.05 |
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H&E Staining |
Slide |
3.59 |
4.85 |
7.00 |
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Bone Tissue Decalcification |
sample |
18.65 |
25.18 |
36.37 |
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Cell Pellet Making, Processing & Embedding |
each |
85.00 |
114.75 |
165.75 |
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Coring Block/ Scraping slide for DNA/RNA Extraction |
Slide |
6.92 |
9.34 |
13.50 |
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IHC Service (Primary Antibody not included) |
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Antibody Optimization |
EA |
300.00 |
405.00 |
585.00 |
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IHC staining |
Slide |
36.96 |
49.90 |
72.07 |
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IHC Dual Staining_chromogenic |
Slide |
63.69 |
85.98 |
124.20 |
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Multi-plex FIHC Optimization |
Panel |
900.00 |
1215.00 |
1755.00 |
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Multi-plex FIHC_Mono control |
Slide |
65.00 |
87.75 |
126.75 |
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Multi-plex FIHC_3 markers |
Slide |
95.00 |
128.25 |
185.25 |
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Multi-plex FIHC_4 markers |
Slide |
125.00 |
168.75 |
243.75 |
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Multi-plex FIHC_5 markers |
Slide |
155.00 |
209.25 |
302.25 |
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Multi-plex FIHC_ 6 markers |
Slide |
185.00 |
249.75 |
360.75 |
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InSitu hybridization (Probe/KIT not included) |
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RNA ISH Optimization |
Probe |
580.00 |
783.00 |
1131.00 |
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RNA ISH |
Slide |
90.00 |
121.50 |
175.50 |
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Multiplex Fluorecense RNA ISH |
Slide |
125.00 |
168.75 |
243.75 |
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TUNEL Staining |
Slide |
63.52 |
85.75 |
123.26 |
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LCM |
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LCM (Core operated) |
Round (Three Slides) |
150.00 |
202.50 |
292.50 |
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LCM Training (including supplies, reagents, sections and labor) |
Round |
800.00 |
1080.00 |
1560.00 |
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Equpment Access (for Trained Users only) |
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LCM Equpment Access (users prepare all supplies) |
Hour |
50.00 |
67.50 |
97.50 |
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Cryostat Equpment Access (users prepare all supplies) |
Hour |
25.00 |
33.75 |
48.75 |
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GeoMX DSP Assays |
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GeoMx DSP Protein Assay_Biopsy/Surgical (NOTE: Minimum 12 slides/project, will charge for 12 slides if less) |
Slide |
350.00 |
472.50 |
682.50 |
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GeoMx DSP Protein Assay_TMA slide |
Per 12 Cores |
350.00 |
472.50 |
682.50 |
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GeoMx DSP RNA Assay_Biopsy/Surgical tissue (NOTE: Minimum 4 slides/project, will charge for 4 slides if less) |
Slide |
380.00 |
513.00 |
741.00 |
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GeoMx DSP RNA Assay__TMA slide |
Per 12 Cores |
350.00 |
472.50 |
682.50 |
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GeoMx Cancer Transcriptome Atlas (CTA) Assay (NOTE: Minimum 4 slides/project, will charge for 4 slides if less) |
Slide |
330.00 |
445.50 |
643.50 |
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GeoMx Whole Transcriptome Atlas (WTA) Assay (NOTE: Minimum 4 slides/project, will charge for 4 slides if less) |
Slide |
350.00 |
472.50 |
682.50 |
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Spectral Imaging |
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Whole Slide Scan (10x) - Brightfield |
Slide |
9.00 |
12.15 |
17.55 |
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Whole Slide Image Acquisition (20x) - Brightfield |
Slide |
18.00 |
24.00 |
31.00 |
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TMA Whole Slide Scan (10X)- Brightfield |
Slide |
10.00 |
13.50 |
19.50 |
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TMA Whole Slide Image Acquisition (20x) - Brightfield |
Slide |
52.00 |
70.20 |
101.40 |
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Whole Slide Image Acquisition (10x) - Fluorescence |
Slide |
16.00 |
21.60 |
31.20 |
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Whole Slide Image Acquisition (20x) - Fluorescence_Biopsy |
Slide |
50.00 |
67.50 |
97.50 |
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Whole Slide Image Acquisition (20x) - Fluorescence_Non-Biopsy |
Slide |
80.00 |
108.00 |
156.00 |
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Image Analysis - Brightfield |
Slide |
50.00 |
67.50 |
97.50 |
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Image Analysis - Fluorescence |
Slide |
138.00 |
186.30 |
269.10 |
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Molecular Pathology |
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DNA Extraction and Quant_for LCM or scraping samples |
sample |
65.00 |
75.00 |
90.00 |
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RNA Extraction and Quant_for LCM or scraping samples |
sample |
65.00 |
75.00 |
90.00 |
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DNA/RNA QC_Bioanalyzer |
sample |
20.00 |
27.00 |
39.00 |
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