Experimental Therapeutics Core (ETx)

Overview of Services

The Experimental Therapeutics (ETx) Core is a preclinical resource to Dana-Farber Cancer Institute (DFCI) researchers and collaborators for conducting in vivo pharmacological studies. Studies will be run at a 14,000-square-foot preclinical facility shared with the Lurie Family Imaging Center (LFIC) that features bioluminescent imaging using the IVIS Spectrum system.

 

Our mission is to help DFCI investigators by providing high quality in vivo pharmacology studies that enable DFCI investigators’ translational research and chemistry and drug discovery/development efforts. These include studies that determine efficacy of new therapies and new combinations, advance preclinical studies to initiate clinical trials, and target identification and validation.

 

The Experimental Therapeutics Core will provide expertise for in vivo pharmacology studies, including drug tolerability and efficacy studies; pharmacodynamic and mechanism-of-action studies, and tumor model development. Our capabilities include both subcutaneous and orthotopic tumor implantations and animal dosing by all common routes of administration, e.g. intraperitoneal, intravenous, oral and subcutaneous, and in combination. Comprehensive tumor and tissue harvesting is available for every study. Fresh samples can be sent to investigators or preserved by formalin fixation and/or flash freezing.

Information for Users External to DFCI

Purchase Orders are to be made out to:

Dana Farber Cancer Institute

General Accounting, BP-430

450 Brookline Avenue

Boston, MA 02215-5450

 

Note to Partners, Harvard, Boston Children’s and Tufts researchers etc:

  • Beth Israel Deaconess Medical Center – supplier 54532
  • Boston Children’s Hospital – use vendor 0000001886; choose address 69
  • Cincinnati Children’s Hospital – use supplier 0000000963
  • City of Hope – use vendor 0000002690
  • Columbia University – use vendor 0000001028
  • Harvard (includes HMS, Dental, Wyss, HSPH, Harvard U – main campus):  choose vendor site:   01_PRIMARY
  • MD Anderson:  choose vendor code 6423
  • Northwestern University – use vendor code 0000017860
  • Partners Health Care (now known as Mass General/Brigham) (includes MGH, BWH, McLean, Spaulding, etc):  choose vendor 0000008573
  • Tufts University:  choose Supplier 0000000655

 If you are using a PO from an institution other than one under which you signed in, you must stop and contact the DFCI iLab staff at sc_billing@dfci.harvard.edu


 

Leadership

Prafulla Gokhale, Ph.D., Head of the Experimental Therapeutics Core

Administrative Contacts

Debbie Taylor-Nicoleau, Core Administration, Experimental Therapeutics Core

 

Location and hours of operation

Hours Location

8:00 AM - 4:00 PM  

27 Dry Dock Ave, Boston, MA 02210

 

Links and Resources

  1. To register for an ilab account, please click here.
  2. To initiate a project go to the Request Services Tab and click Initate a project.
  3. ARF: http://dfciarf.partners.org/main.aspx

Contacts

Name Role Phone Email Location
Debbie Taylor-Nicoleau
Program Coordinator
 
(617) 582-8969
 
Debbie_Taylor-Nicoleau@dfci.harvard.edu
 
DD-109
 
Dr. Praful Gokhale
Head of the Experimental Therapeutics Core
 
(617) 632-6919
 
Prafulla_Gokhale@dfci.harvard.edu